Diseases Treated With Stem Cell Therapy

Stem cell therapy is used in regenerative medicine to repair or replace damaged cells and tissues. It is applied across a wide range of conditions, particularly those involving inflammation, degeneration, or immune system dysfunction.

At ANOVA Institute for Regenerative Medicine (ANOVA IRM), treatment is focused on several key categories, including neurodegenerative diseases, autoimmune disorders, orthopaedic conditions, and chronic or systemic illnesses.

This page outlines the main conditions treated within each category and how stem cell therapy may be applied as part of a personalized treatment approach.

 

 Explore All Conditions Treated With Stem Cell Therapy

Multiple Sclerosis

Multiple Sclerosis

Rheumatoid Arthritis

Rheumatoid Arthritis

ALS

ALS

Parkinson's Disease

Parkinson's Disease

Osteoarthritis

Osteoarthritis

Knee Injuries

Knee Injuries

Back Pain

Back Pain

Erectile Dysfunction

Erectile Dysfunction

Spinal Cord Injury

Spinal Cord Injury

Stroke

Stroke

Lyme Disease

Lyme Disease

Dry Mouth

Dry Mouth

Diabetes

Diabetes

Urinary Incontinence

Urinary Incontinence

COPD

COPD

Conditions Treated With Stem Cell Therapy at ANOVA IRM

Stem cell therapy continues to be studied and developed across a wide range of medical applications. It is most commonly used in conditions affecting joints, the nervous system, and the immune system.

At ANOVA IRM, treatment is focused on several key condition categories, outlined below.

Neurodegenerative Diseases

Many neurodegenerative diseases involve disruptions in normal cell regeneration processes. These conditions are often associated with immune system dysfunction and the accumulation of waste materials within cells. Stem cell therapies can intervene at all levels of this process.

Autologous mesenchymal stem cells (MSCs) have been central to advancements in this area due to their neuroprotective and immunomodulatory properties, and their ability to transdifferentiate into neural cells under specific conditions.

At ANOVA IRM, we currently apply stem cell therapies for the following neurodegenerative diseases:

Learn how stem cells are used to treat neurodegenerative diseases →

Autoimmune Diseases

Stem cell therapies can be used to treat autoimmune diseases such as rheumatoid arthritis and other inflammatory immune conditions. This is largely due to their ability to help regulate immune responses and reduce inflammation while supporting tissue repair.

In more advanced approaches, Stem Cell Secretome (SCS) may also be used in conditions such as multiple sclerosis, where autoimmune damage affects the myelin sheath of nerve cells. In Europe, ANOVA is the first clinic to offer this treatment.

At ANOVA IRM, stem cell therapy is currently offered for the following autoimmune conditions:

Learn how stem cells are used to treat autoimmune diseases →

Orthopaedic Conditions and Sport Injuries

Orthopaedic conditions typically involve joint degeneration, inflammation, or damage to structures such as cartilage, discs, and ligaments. These issues may develop gradually or result from injury and overuse.

While conventional treatments often focus on symptom relief, stem cell therapies are used to support tissue repair and improve joint function.

At ANOVA IRM, treatment is available for:

Learn how stem cells are used to treat orthopaedic conditions and sport injuries →

Chronic and Systemic Conditions

Chronic and systemic conditions often affect multiple systems within the body and can involve long-term inflammation, tissue damage, or functional decline. In many cases, treatment options are limited and focused on managing symptoms rather than improving underlying function.

Because these conditions involve broader, system-wide processes, stem cell therapies are being explored as a way to support repair at a more systemic level.

At ANOVA IRM, stem cell therapies are applied across conditions including:

The Role of Diagnostics in Treatment Planning

Before stem cell treatment begins, patients undergo a comprehensive diagnostic work-up to guide planning and determine where stem cells should be applied based on their condition. Because different conditions can present with similar symptoms, an accurate diagnosis is essential to select the most appropriate approach.

Founded by Dr. mult. Michael K. Stehling, a radiologist and physicist, ANOVA IRM works in cooperation with the Prof. Stehling Institute for Diagnostic Imaging to provide advanced diagnostic techniques, including arthro-MRI and non-radioactive contrast MRI.

These methods help localize the source of pain or inflammation, allowing treatment to be applied more precisely compared to standard diagnostic approaches.

Discover Our Full Diagnostic Work-Up →

ANOVA IRM Full-body MRI scan of human anatomy for stem cell therapy

MRI imaging used to guide stem cell therapy treatment Source: Siemens Healthcare

How Stem Cell Therapy Is Applied Across Different Conditions

Stem cell therapy is used in regenerative medicine to heal and restore damaged tissues and organs. The source and application of treatment vary depending on the condition, and many of these therapies are considered experimental when conventional options are limited.

At ANOVA IRM, all therapies are based on autologous stem cell treatments, meaning the cells are taken from the individual patient. This approach minimizes the risk of disease transmission and adverse immune reactions that can occur with donor-derived cells.

Bone Marrow Concentrate (BMC) and Mesenchymal Stem Cells (MSCs) are among the most commonly used forms of adult stem cells and are harvested from bone marrow or subcutaneous fat tissue. In addition to cell-based therapies, ANOVA also offers Stem Cell Secretome, a cell-free therapy that uses regenerative factors released by stem cells to support healing and immune regulation.

Depending on the condition, treatments may be applied locally to targeted areas or used more broadly to support systemic processes such as immune function. The specific approach is always selected based on the patient’s condition, treatment goals, and diagnostic findings.

Learn more about our stem cell therapies →

ANOVA IRM Deutschland CT-guided stem cell injection into joint tissue
Targeted stem cell therapy to repair specialized cells Source: Siemens Healthcare

What Stem Cell Therapy Can and Cannot Do for These Conditions

While stem cell therapy can support the repair of damaged tissue and improve function in certain medical conditions, it is not a cure-all solution. Many applications are still considered experimental, and it is important to understand both the potential benefits and limitations.

What stem cell therapy may do

  • Support the repair of damaged or injured tissue
  • Help regenerate or support the formation of new tissue
  • Modulate inflammatory responses in chronic conditions
  • Improve function or reduce symptoms depending on the condition
  • Support specific biological functions depending on the condition being treated

What stem cell therapy cannot guarantee

  • Stem cell therapy is not a guaranteed cure for all conditions
  • Results vary based on the type and progression of the disease
  • Outcomes are often focused on symptom improvement and functional support rather than complete reversal
  • Not all medical conditions respond equally to treatment

Safety and Considerations

Many stem cell therapies are experimental and, like other medical procedures, carry risks such as infection, immune reactions, and procedure-related complications. Risk levels vary by condition, therapy type, and individual patient factors.

When considering treatment, several important factors can influence safety and outcomes:

  • Source of stem cells: Treatments using donor-derived cells may carry a higher risk of immune reactions or disease transmission compared to cells derived from the patient’s own body
  • Processing and quality control: The way stem cell products are handled, tested, and prepared can impact safety and consistency
  • Clinical oversight: Proper diagnostics, medical supervision, and individualized planning are essential for appropriate treatment
  • Regulatory standards: Treatments performed within regulated medical frameworks are subject to quality and safety controls

At ANOVA IRM, treatments follow a regulated German medical framework and use autologous stem cells derived from the patient’s own body. Stem cell products are prepared under controlled laboratory conditions in accordance with GMP and the European Pharmacopoeia, supporting a consistent and individualized treatment approach.

Who May Be a Candidate for Stem Cell Therapy?

Patients with certain neurological, orthopaedic, autoimmune, or chronic medical conditions may be considered for stem cell therapy, particularly those involving inflammation, tissue damage, or functional decline.

Eligibility depends on several factors, including the specific diagnosis, the stage and progression of the disease, and overall health. Because medical conditions can vary significantly, not all patients are suitable for treatment.

A full medical evaluation is required to determine whether stem cell therapy may be appropriate for an individual case.

Considering Stem Cell Therapy?

If you may be a candidate for stem cell therapy, the next step is a detailed medical evaluation to determine whether treatment is appropriate for your condition.

ANOVA IRM offers personalized consultations to review your medical history, diagnostic imaging (such as MRI, CT, or X-ray), and treatment options. Consultations can be conducted remotely by phone or video, with on-site evaluations available if needed.

Our team will guide you through the process, including what information is required and how your case will be assessed.

Request a consultation →

Frequently Asked Questions

Which conditions can be treated with stem cell therapy?

Stem cell therapy is used for a range of conditions involving inflammation, degeneration, or immune system dysfunction. These include neurological disorders such as amyotrophic lateral sclerosis and spinal cord injury, orthopaedic conditions such as osteoarthritis, and various chronic or systemic diseases.

Can stem cell therapy cure diseases?

Stem cell therapy is not considered a cure for most conditions. While stem cell research continues to explore new possibilities, many applications are still being evaluated in clinical trials. Treatment is typically focused on supporting tissue repair, reducing inflammation, and improving function rather than fully curing disease.

How do I know if I am a candidate for stem cell therapy?

Eligibility depends on several factors, including the diagnosis, stage of the condition, and overall health. Patients with chronic or degenerative conditions may be considered, but a full medical evaluation is required to determine whether treatment is appropriate.

Is stem cell therapy safe?

Like many medical procedures, stem cell therapy carries potential risks, including infection, immune reactions, and procedure-related complications. Safety depends on factors such as the type of therapy, clinical oversight, and whether treatment is performed using a patient’s own cells within a regulated medical setting.

How is stem cell therapy tailored to different medical conditions?

Treatment approaches vary depending on the condition being treated. Factors such as the location of the affected tissue, the underlying cause of the condition, and individual patient characteristics all influence how stem cells are applied. Diagnostic findings play a key role in determining the most appropriate treatment plan.

What types of stem cell therapies are used?

Common approaches include Bone Marrow Concentrate (BMC) and mesenchymal stem cells (MSCs), both of which are used in adult stem cell–based therapies derived from the patient’s own body. These differ from therapies such as blood stem cell transplants used in other areas of medicine. The appropriate treatment is selected based on the condition and therapeutic goals.

How much does stem cell therapy cost?

Costs can vary depending on the condition being treated, the type of therapy used, and the complexity of the treatment plan. A personalized consultation is typically required to provide an accurate estimate.

Is stem cell therapy covered by insurance?

In most cases, stem cell therapy is not covered by insurance, as many applications are still considered experimental and under further research. Coverage may vary depending on the provider, country, and specific treatment.

  1. Georg Hansmann, Philippe Chouvarine, Franziska Diekmann, Martin Giera, Markus Ralser, Michael Mülleder, Constantin von Kaisenberg, Harald Bertram, Ekaterina Legchenko & Ralf Hass "Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension". Nature Cardiovascular Research volume 1, pages568–576 (2022).
  2. Murphy JM, Fink DJ, Hunziker EB, et al. Stem cell therapy in a caprine model of osteoarthritis . Arthritis Rheum. 2003;48:3464–74.
  3. Lee KB, Hui JH, Song IC, Ardany L, et al. Injectable mesenchymal stem cell therapy for large cartilage defects—a porcine model. Stem Cell. 2007;25:2964–71.
  4. Saw KY, Hussin P, Loke SC, et al. Articular cartilage regeneration with autologous marrow aspirate and hyaluronic acid: an experimental study in a goat model. Arthroscopy . 2009;25(12):1391–400.
  5. Black L, Gaynor J, Adams C, et al. Effect of intra-articular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther. 2008;9:192-200.
  6. Centeno C, Busse D, Kisiday J, et al. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–53.
  7. Centeno C, Kisiday J, Freeman M, et al. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: a case study. Pain Physician. 2006;9:253–6.
  8. Centeno C, Schultz J, Cheever M. Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell. 2011;5(1):81–93.
  9. Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose derived stem cells: a case series. J Med Case Rep. 2001;5:296.
  10. Kuroda R, Ishida K, et al. Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. Osteoarthritis Cartilage. 2007;15:226–31.
  11. Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012;15(7):422–8.
  12. Saw KY et al. Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial. Arthroscopy. 2013;29(4):684–94.
  13. Vangsness CT, Farr J, Boyd J, et al. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy. J Bone Joint Surg. 2014;96(2):90–8.
  14. Freitag, Julien, et al. Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review. BMC musculoskeletal disorders 17.1 (2016): 230.
  15. Maumus, Marie, Christian Jorgensen, and Danièle Noël. " Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. " Biochimie 95.12 (2013): 2229-2234.
  16. Dostert, Gabriel, et al. " How do mesenchymal stem cells influence or are influenced by microenvironment through extracellular vesicles communication?. " Frontiers in Cell and Developmental Biology 5 (2017).
  17. Chaparro, Orlando, and Itali Linero. " Regenerative Medicine: A New Paradigm in Bone Regeneration. " (2016).
  18. Toh, Wei Seong, et al. " MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. " Seminars in Cell & Developmental Biology. Academic Press, 2016.
  19. Chaparro, Orlando, and Itali Linero. " Regenerative Medicine: A New Paradigm in Bone Regeneration. " (2016).
  20. S. Koelling, J. Kruegel, M. Irmer, J.R. Path, B. Sadowski, X. Miro, et al., Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis , Cell Stem Cell 4 (2009) 324–335.
  21. B.A. Jones, M. Pei, Synovium-Derived stem cells: a tissue-Specific stem cell for cartilage engineering and regeneration , Tissue Eng. B: Rev. 18 (2012) 301–311.
  22. W. Ando, J.J. Kutcher, R. Krawetz, A. Sen, N. Nakamura, C.B. Frank, et al., Clonal analysis of synovial fluid stem cells to characterize and identify stable mesenchymal stromal cell/mesenchymal progenitor cell phenotypes in a porcine model: a cell source with enhanced commitment to the chondrogenic lineage, Cytotherapy 16 (2014) 776–788.
  23. K.B.L. Lee, J.H.P. Hui, I.C. Song, L. Ardany, E.H. Lee, Injectable mesenchymal stem cell therapy for large cartilage defects—a porcine model, Stem Cells 25 (2007) 2964–2971.
  24. W.-L. Fu, C.-Y. Zhou, J.-K. Yu, A new source of mesenchymal stem cells for articular cartilage repair: mSCs derived from mobilized peripheral blood share similar biological characteristics in vitro and chondrogenesis in vivo as MSCs from bone marrow in a rabbit model , Am. J. Sports Med. 42 (2014) 592–601.
  25. X. Xie, Y. Wang, C. Zhao, S. Guo, S. Liu, W. Jia, et al., Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration , Biomaterials 33 (2012) 7008–7018.
  26. E.-R. Chiang, H.-L. Ma, J.-P. Wang, C.-L. Liu, T.-H. Chen, S.-C. Hung, Allogeneic mesenchymal stem cells in combination with hyaluronic acid for the treatment of osteoarthritis in rabbits , PLoS One 11 (2016) e0149835.
  27. H. Nejadnik, J.H. Hui, E.P. Feng Choong, B.-C. Tai, E.H. Lee, Autologous bone marrow–derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study , Am. J. Sports Med. 38 (2010) 1110–1116.
  28. I. Sekiya, T. Muneta, M. Horie, H. Koga, Arthroscopic transplantation of synovial stem cells improves clinical outcomes in knees with cartilage defects , Clin. Orthop. Rel. Res. 473 (2015) 2316–2326.
  29. Y.S. Kim, Y.J. Choi, Y.G. Koh, Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes , Am. J. Sports Med. 43 (2015) 2293–2301.
  30. W.-L. Fu, Y.-F. Ao, X.-Y. Ke, Z.-Z. Zheng, X. Gong, D. Jiang, et al., Repair of large full-thickness cartilage defect by activating endogenous peripheral blood stem cells and autologous periosteum flap transplantation combined with patellofemoral realignment , Knee 21 (2014) 609–612.
  31. Y.-G. Koh, O.-R. Kwon, Y.-S. Kim, Y.-J. Choi, D.-H. Tak, Adipose-derived mesenchymal stem cells with microfracture versus microfracture alone: 2-year follow-up of a prospective randomized trial , Arthrosc. J. Arthrosc. Relat. Surg. 32 (2016) 97–109.
  32. T.S. de Windt, L.A. Vonk, I.C.M. Slaper-Cortenbach, M.P.H. van den Broek, R. Nizak, M.H.P. van Rijen, et al., Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-Stage cartilage repair in humans upon mixture with recycled autologous chondrons , Stem Cells (2016) (n/a-n/a).
  33. L. da Silva Meirelles, A.M. Fontes, D.T. Covas, A.I. Caplan, Mechanisms involved in the therapeutic properties of mesenchymal stem cells , Cytokine Growth Factor Rev. 20 (2009) 419–427.
  34. W.S. Toh, C.B. Foldager, M. Pei, J.H.P. Hui, Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration , Stem Cell Rev. Rep. 10 (2014) 686–696.
  35. R.C. Lai, F. Arslan, M.M. Lee, N.S.K. Sze, A. Choo, T.S. Chen, et al., Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury , Stem Cell Res. 4 (2010) 214–222.
  36. S. Zhang, W.C. Chu, R.C. Lai, S.K. Lim, J.H.P. Hui, W.S. Toh, Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration, Osteoarthr . Cartil. 24 (2016) 2135–2140.
  37. S. Zhang, W. Chu, R. Lai, J. Hui, E. Lee, S. Lim, et al., 21 – human mesenchymal stem cell-derived exosomes promote orderly cartilage regeneration in an immunocompetent rat osteochondral defect model , Cytotherapy 18 (2016) S13.
  38. C.T. Lim, X. Ren, M.H. Afizah, S. Tarigan-Panjaitan, Z. Yang, Y. Wu, et al., Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model
  39. A. Gobbi, G. Karnatzikos, S.R. Sankineani, One-step surgery with multipotent stem cells for the treatment of large full-thickness chondral defects of the knee , Am. J. Sports Med. 42 (2014) 648–657.
  40. A. Gobbi, C. Scotti, G. Karnatzikos, A. Mudhigere, M. Castro, G.M. Peretti, One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years , Knee Surg. Sports Traumatol. Arthrosc. (2016) 1–8.
  41. A. Gobbi, G. Karnatzikos, C. Scotti, V. Mahajan, L. Mazzucco, B. Grigolo, One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: results at 2-Year follow-up , Cartilage 2 (2011) 286–299.
  42. K.L. Wong, K.B.L. Lee, B.C. Tai, P. Law, E.H. Lee, J.H.P. Hui, Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years’ follow-up , Arthrosc. J. Arthrosc. Relat. Surg. 29 (2013) 2020–2028.
  43. J.M. Hare, J.E. Fishman, G. Gerstenblith, et al., Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the poseidon randomized trial, JAMA 308 (2012) 2369–2379.
  44. L. Wu, J.C.H. Leijten, N. Georgi, J.N. Post, C.A. van Blitterswijk, M. Karperien, Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation , Tissue Eng. A 17 (2011) 1425–1436.
  45. L. Wu, H.-J. Prins, M.N. Helder, C.A. van Blitterswijk, M. Karperien, Trophic effects of mesenchymal stem cells in chondrocyte Co-Cultures are independent of culture conditions and cell sources , Tissue Eng. A 18 (2012) 1542–1551.
  46. S.K. Sze, D.P.V. de Kleijn, R.C. Lai, E. Khia Way Tan, H. Zhao, K.S. Yeo, et al., Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells , Mol. Cell. Proteomics 6 (2007) 1680–1689.
  47. M.B. Murphy, K. Moncivais, A.I. Caplan, Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine , Exp. Mol. Med. 45 (2013) e54.
  48. M.J. Lee, J. Kim, M.Y. Kim, Y.-S. Bae, S.H. Ryu, T.G. Lee, et al., Proteomic analysis of tumor necrosis factor--induced secretome of human adipose tissue-derived mesenchymal stem cells , J. Proteome Res. 9 (2010) 1754–1762.
  49. S. Bruno, C. Grange, M.C. Deregibus, R.A. Calogero, S. Saviozzi, F. Collino, et al., Mesenchymal stem cell-derived microvesicles protect against acute tubular injury, J. Am. Soc. Nephrol. 20 (2009) 1053–1067.
  50. M. Yá˜nez-Mó, P.R.-M. Siljander, Z. Andreu, A.B. Zavec, F.E. Borràs, E.I. Buzas, et al. Biological properties of extracellular vesicles and their physiological functions (2015).
  51. C. Lawson, J.M. Vicencio, D.M. Yellon, S.M. Davidson, Microvesicles and exosomes: new players in metabolic and cardiovascular disease , J. Endocrinol. 228 (2016) R57–R71.
  52. A.G. Thompson, E. Gray, S.M. Heman-Ackah, I. Mager, K. Talbot, S.E. Andaloussi, et al., Extracellular vesicles in neurodegenerative diseas—pathogenesis to biomarkers, Nat. Rev. Neurol. 12 (2016) 346–357.
  53. I.E.M. Bank, L. Timmers, C.M. Gijsberts, Y.-N. Zhang, A. Mosterd, J.-W. Wang, et al., The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease , Expert Rev. Mol. Diagn. 15 (2015) 1577–1588.
  54. T. Kato, S. Miyaki, H. Ishitobi, Y. Nakamura, T. Nakasa, M.K. Lotz, et al., Exosomes from IL-1 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes , Arthritis. Res. Ther. 16 (2014) 1–11.
  55. R.W.Y. Yeo, S.K. Lim, Exosomes and their therapeutic applications, in: C. Gunther, A. Hauser, R. Huss (Eds.), Advances in Pharmaceutical Cell TherapyPrinciples of Cell-Based Biopharmaceuticals, World Scientific, Singapore, 2015, pp. 477–491.
  56. X. Qi, J. Zhang, H. Yuan, Z. Xu, Q. Li, X. Niu, et al., Exosomes secreted by human-Induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats , Int. J. Biol. Sci. 12 (2016) 836–849.
  57. R.C. Lai, F. Arslan, S.S. Tan, B. Tan, A. Choo, M.M. Lee, et al., Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles , J. Mol. Cell. Cardiol. 48 (2010) 1215–1224.
  58. Y. Zhou, H. Xu, W. Xu, B. Wang, H. Wu, Y. Tao, et al., Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro , Stem Cell Res. Ther. 4 (2013) 1–13.
  59. Y. Qin, L. Wang, Z. Gao, G. Chen, C. Zhang, Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo , Sci. Rep. 6 (2016) 21961.
  60. M. Nakano, K. Nagaishi, N. Konari, Y. Saito, T. Chikenji, Y. Mizue, et al., Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes , Sci. Rep. 6 (2016) 24805.
  61. K. Nagaishi, Y. Mizue, T. Chikenji, M. Otani, M. Nakano, N. Konari, et al., Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes , Sci. Rep. 6 (2016) 34842.
  62. S.R. Baglio, K. Rooijers, D. Koppers-Lalic, F.J. Verweij, M. Pérez Lanzón, N. Zini, et al., Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species , Stem Cell Res. Ther. 6 (2015) 1–20.
  63. T. Chen, R. Yeo, F. Arslan, Y. Yin, S. Tan, Efficiency of exosome production correlates inversely with the developmental maturity of MSC donor, J. Stem Cell Res. Ther. 3 (2013) 2.
  64. R.C. Lai, S.S. Tan, B.J. Teh, S.K. Sze, F. Arslan, D.P. de Kleijn, et al., Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome , Int. J. Proteomics 2012 (2012) 971907.
  65. T.S. Chen, R.C. Lai, M.M. Lee, A.B.H. Choo, C.N. Lee, S.K. Lim, Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs , Nucleic Acids Res. 38 (2010) 215–224.
  66. R.W. Yeo, R.C. Lai, K.H. Tan, S.K. Lim, Exosome: a novel and safer therapeutic refinement of mesenchymal stem cell, J. Circ. Biomark. 1 (2013) 7.
  67. R.C. Lai, R.W. Yeo, S.K. Lim, Mesenchymal stem cell exosomes, Semin. Cell Dev. Biol. 40 (2015) 82–88.
  68. B. Zhang, R.W. Yeo, K.H. Tan, S.K. Lim, Focus on extracellular vesicles: therapeutic potential of stem cell-derived extracellular vesicles , Int. J. Mol. Sci. 17 (2016) 174.
  69. Hu G-w, Q. Li, X. Niu, B. Hu, J. Liu, Zhou S-m, et al., Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice , Stem Cell Res. Ther. 6 (2015) 1–15.
  70. J. Zhang, J. Guan, X. Niu, G. Hu, S. Guo, Q. Li, et al., Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis , J. Transl. Med. 13 (2015) 1–14.
  71. B. Zhang, M. Wang, A. Gong, X. Zhang, X. Wu, Y. Zhu, et al., HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing, Stem Cells 33 (2015) 2158–2168.
  72. B. Zhang, Y. Yin, R.C. Lai, S.S. Tan, A.B.H. Choo, S.K. Lim, Mesenchymal stem cells secrete immunologically active exosomes , Stem Cells Dev. 23 (2013) 1233–1244.
  73. C.Y. Tan, R.C. Lai, W. Wong, Y.Y. Dan, S.-K. Lim, H.K. Ho, Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models , Stem Cell Res. Ther. 5 (2014) 1–14.
  74. C. Lee, S.A. Mitsialis, M. Aslam, S.H. Vitali, E. Vergadi, G. Konstantinou, et al., Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension , Circulation 126 (2012) 2601–2611.
  75. B. Yu, H. Shao, C. Su, Y. Jiang, X. Chen, L. Bai, et al., Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1 , Sci. Rep. 6 (2016) 34562.
  76. Jo CH, Lee YG, Shin WH, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof of concept clinical trial. Stem Cells. 2014;32(5):1254–66.
  77. Vega, Aurelio, et al. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. Transplantation. 2015;99(8):1681–90.
  78. Davatchi F, Sadeghi-Abdollahi B, Mohyeddin M, et al. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211–5
  79. Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case- controlled study. Int Orthop. 2014;38(9):1811–1818
  80. Galli D, Vitale M, Vaccarezza M. Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: facts and perspectives. Biomed Res Int. 2014;2014:6.
  81. Beitzel K, Solovyova O, Cote MP, et al. The future role of mesenchymal Stem cells in The management of shoulder disorders . Arthroscopy. 2013;29(10):1702–1711.
  82. Isaac C, Gharaibeh B, Witt M, Wright VJ, Huard J. Biologic approaches to enhance rotator cuff healing after injury. J Shoulder Elbow Surg. 2012;21(2):181–190.
  83. Malda, Jos, et al. " Extracellular vesicles [mdash] new tool for joint repair and regeneration. " Nature Reviews Rheumatology (2016).

  1. Xu, Ming, et al. " Transplanted senescent cells induce an osteoarthritis-like condition in mice. " The Journals of Gerontology Series A: Biological Sciences and Medical Sciences (2016): glw154.
  2. McCulloch, Kendal, Gary J. Litherland, and Taranjit Singh Rai. " Cellular senescence in osteoarthritis pathology ." Aging Cell (2017).

Contraindications

Our stem cell treatments are experimental, but we only treat patients for whom we believe the risk/benefit ratio indicates treatment based on the state of the art, i.e., medical, scientific evidence.

Please understand that we therefore do not treat patients for whom the following points apply:

  • Active cancer in the last two years
  • Not yet of legal age
  • Existing pregnancy or lactation period
  • Unable to breathe on own, ventilator
  • Difficulty breathing in supine position
  • Dysphagia (extreme difficulty swallowing)
  • Psychiatric disorder
  • Active infectious disease (Hepatitis A, B, C, HIV, Syphilis, or other)