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BMC - Bone Marrow Stem Cell Therapy
ANOVA Institute for Regenerative Medicine - Offenbach, Germany

BMC is an innovative and minimally invasive therapeutic approach for one-time treatment of local problems, such as improving your orthopedic well-being and reducing pain from osteoarthritis, accelerating the healing of ligament and tendon injuries, tennis arm or elbow, problems of the hip, intervertebral discs or spine. Stem cell concentrate therapy is not to be confused with bone marrow transplantation, which is used for cancers such as blood cancers or lymphoma. Learn more about bone marrow concentrate and your personal treatment options at ANOVA Institue for Regenerative Medicine here.

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We Treat the Following Conditions With BMC:

  • Osteoarthritis
  • Knee - Meniscus Tears (medial and lateral), Chondromalacia Patella, Tendon Injuries (Patellar Tendonitis, Quad Tendon), Ligament sprains or tears (MCL, LCL, ACL)
  • Hip - Hip Labrum Tears, SI Joint Dysfunction, Piriformis Syndrome, Greater Trochanteric Bursitis, Iliotibial Band (ITB) Syndrome
  • Shoulder - Rotator Cuff Tendinitis, Tendonopathy, or Partial Tears, Labrum Tear, Bicipital Tendinitis
  • Elbow - Lateral Epicondylitis (Tennis Elbow), Medial Epicondylitis (Golfers Elbow)
  • Hand or Wrist Pain - DeQuervain's Tenosynovitis
  • Ankle & Foot Pain - Achilles Tendinitis or Partial Tears, Plantar Fasciitis, Ankle sprains or ligament injury
  • Spine - Facet Joint Arthropathy. Sacroiliac (SI) Joint Dysfunction

What is BMC - What is Bone Marrow Concentrate?

Bone Marrow Concentrate (BMC) is a fluid taken from the patient's iliac crest. It consists of blood and bone marrow stem cells, which are flushed out of the pelvic bone together when BMC is taken out using a syringe. The composition thus corresponds to the natural composition of a mixture of blood and bone marrow.

This mixture contains, among others, hematopoietic stem cells and so-called mesenchymal stem cells (named after their belonging to the middle layer of the body, the mesenchyme). In addition, the white blood cells found in the blood, such as myeloid cells (neutrophils, basophils, eosinophils, monocytes) and platelets, as well as lymphoid white blood cells (T cells and B cells).

BMC bone marrow concentrate stem cells | Germany

BMC - Bone Marrow Concentrate
ANOVA IRM - Germany

Why is BMC a Stem Cell Concentrate?

BMC is named a stem cell concentrate because after the minimally invasive collection, the stem cells are concentrated to obtain as many stem cells as possible in little blood serum.

Blood serum and erythrocytes (red blood cells) are partially excluded from BMC, thereby increasing the stem cells concentration per mL.

This is especially important when the stem cells are to be injected into small joints because the joint space is very small. However, no further manipulation takes place on the BMCs.

The stem cells composition is the natural composition of bone marrow concentrated by approximately 6x.

The stem cells are not further manipulated, not cultivated or multiplied. They are re-applied directly after the finalization of all quality control tests.

The whole procedure of donation, concentration, quality control and re-application takes 1,5 hours.

BMC-therapy-stem-cells-procedure | Germany

BMC - Bone Marrow Concentrate Procedure
ANOVA IRM - Germany

Why Do We Get Stem Cells From the Bone Marrow?

Bone marrow can be found in the central region of your bones and is a soft spongy tissue which produces your red bloods cells, white blood cells and blood plasma components. Stem cells (hematopoietic as well as mesenchymal stem cells) can be found in this tissue, as they play a key role in the production of these cell components.

In contrast to other body regions that contain stem cells, the bone marrow is easily accessible and stem cells can be collected in a short, minimally invasive and safe procedure.

Stem cells are known to help advance healing processes and regeneration in tissue, and can be employed in moderate to severe osteoarthritis, tendon injuries and other orthopedic problems.

What Diseases Can Be Treated With BMC?

In general, the following diseases are treatable with BMC, meaning, they represent conditions for which it is probably that patients profit from stem cell treatment. However, we determine for each patient whether in this specific case stem cells are an advisable treatment strategy. Also there are several contraindications such as age under 18 years, pregnancy, breathing difficulties, acute cancer etc. Please inquire with our patient care managers whether BMC would be an option for you.

  • Osteoarthritis
  • Knee - Meniscus Tears (medial and lateral), Chondromalacia Patella, Tendon Injuries (Patellar Tendonitis, Quad Tendon), Ligament sprains or tears (MCL, LCL, ACL)
  • Hip - Hip Labrum Tears, SI Joint Dysfunction, Piriformis Syndrome, Greater Trochanteric Bursitis, Iliotibial Band (ITB) Syndrome
  • Shoulder - Rotator Cuff Tendinitis, Tendonopathy, or Partial Tears, Labrum Tear, Bicipital Tendinitis
  • Elbow - Lateral Epicondylitis (Tennis Elbow), Medial Epicondylitis (Golfers Elbow)
  • Hand or Wrist Pain - DeQuervain's Tenosynovitis
  • Ankle & Foot Pain - Achilles Tendinitis or Partial Tears, Plantar Fasciitis, Ankle sprains or ligament injury
  • Spine - Facet Joint Arthropathy. Sacroiliac (SI) Joint Dysfunction

More medical applications may be possible, please consult our doctors.

BMC Introduction

Figure 1: Plasticity Among Adult Stem Cells. (© 2001 Terese Winslow, Lydia Kibiuk, Caitlin Duckwall)

Workflow of a BMC Therapy

In the schema below we have summarized the steps towards your individual BMC therapy form initial free-of-charge consultation with our patient care managers up the the final BMC application in Offenbach, Germany.

 
anova irm stem cell treatment bone marrow BMC 7 steps

The 7 steps of a BMC Therapy

ANOVA – Leading Expert in the Field of BMC Application

ANOVA, a German clinic for regenerative medicine, is one of the first licensed institutions for BMC in Europe. ANOVA has employed BMC as a non-surgical regenerative treatment for different applications, with focus in orthopedics, since 2011. Talk to our experienced and knowledgeable physicians today, to learn more about your treatment options at ANOVA.

ANOVA has acquired two pharmaceutical manufacturing licenses for stem cell products in 2018 and is therefore,  a continuously authority-controlled clinic. This guarantees you safe, controlled and reliable products.

Contraindications

Our stem cell treatments are experimental, but we only treat patients for whom we believe the risk/benefit ratio indicates treatment based on the state of the art, i.e., medical, scientific evidence.

Please understand that we therefore do not treat patients for whom the following points apply:

  • Active cancer in the last two years
  • Not yet of legal age
  • Existing pregnancy or lactation period
  • Unable to breathe on own, ventilator
  • Difficulty breathing in supine position
  • Dysphagia (extreme difficulty swallowing)
  • Psychiatric disorder
  • Active infectious disease (Hepatitis A, B, C, HIV, Syphilis, or other)

How BMC Therapy Works

Bone Marrow Concentrate (BMC) has the ability to utilize the body’s own ability to regenerate and heal itself through the containing growth factors and regenerative cells. BMC contains pluripotent cells, which means that they are able to turn themselves into various different types of tissue. The detailed mechanisms of stem cell action are not well understood but somehow stem cells are able to stop over-flowing immune reactions thereby reducing or stopping damaging inflammation and thereafter, they are able to stimulate regeneration.

While some types of stem cells have failed to show healing effects in conditions such as stroke and heart diseases, bone marrow stem cells have been proven to be effective for a number of other applications. The data is available at the prestigious Cochrane Library, the international authority for evidence-based medicine.

Interestingly, the previously ignored blood cells of the bone marrow appear to play a pivotal role in many healing processes. They contain high numbers of cells with CD34+ and c-kit surface markers, without which stem cells are ineffective in repairing and regenerating damaged tissues and organs.

The Story of BMC Therapy

Early research in stem cells has focused on investigating the regenerative capabilities of embryonic or adult Mesenchymal Stem Cells. While scientists and doctors still hope they can use these cells for the treatment of many diseases, they cannot be used for treating patients in most countries, due to legal restrictions and safety concerns.

Therefore, doctors and scientists began searching for alternatives to employ this cutting edge approach. Bone marrow stem cells are an obvious alternative. They are abundant, relatively easy to access and both the harvest as well as the application has minimal potential of health risks or side effects.

For many years, critics of stem cell treatments claimed that bone marrow stem cells are not effective, because they mainly contain blood forming cells and only a low number of Mesenchymal Stem Cells (MSCs). In short, the critics claimed that bone marrow stem cell treatment is only good for making money, but not for curing patients. Scientific evidence, however, has shown significant effects of Bone Marrow Cells.

References and Literature - Bone Marrow Concentrate 'BMC'

    1. He Y, He W, Qin G, Luo J, Xiao M. Transplantation KCNMA1 modified bone marrow-mesenchymal stem cell therapy for diabetes mellitus-induced erectile dysfunction. Andrologia. 2014;46(5):479-486. doi:10.1111/and.12104.
  1. Mathiasen AB, Qayyum AA, Jørgensen E, et al. Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial ({MSC}-{HF} trial). Eur Heart J. 2015;36(27):1744-1753. doi:10.1093/eurheartj/ehv136.
  2. Mathiasen AB, Qayyum AA, Jørgensen E, et al. Interventional cardiology Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure : a randomized placebo-controlled trial. 2015. doi:10.1093/eurheartj/ehv136.
  3. Liao H-T, Chen C-T. Osteogenic potential: Comparison between bone marrow and adipose-derived mesenchymal stem cells. World J Stem Cells. 2014;6(3):288-295. doi:10.4252/wjsc.v6.i3.288.
  4. Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells. 2006;24(10):2292-2298. doi:10.1634/stemcells.2005-0542.
  5. 2015_Cao_Spine-Journal_Bone-marrow-mesenchymal-stem-cells-slow-intervertebral-disc-degeneration-through-the-NF-κB-pathway.pdf.
  6. Zhao J, Zhang Q, Wang Y, Li Y. Uterine Infusion With Bone Marrow Mesenchymal Stem Cells Improves Endometrium Thickness in a Rat Model of Thin Endometrium. Reprod Sci. 2015;22(2):181-188. doi:10.1177/1933719114537715.
  7. Fekete N, Rojewski MT, Fürst D, et al. GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PLoS One. 2012;7(8). doi:10.1371/journal.pone.0043255.
  8. Elman JS, Li M, Wang F, Gimble JM, Parekkadan B. A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation. 2014:4-11.
  9. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther. 2015;6(1):55. doi:10.1186/s13287-015-0066-5.
  10. Books J, Sign R. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postrad ... Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction : An Open Dose-Escalation Pilot Study Safety of Intracavernous Bone Marrow-Mon. 2017:2015-2017.
  11. Rinker TE, Hammoudi TM, Kemp ML, Lu H, Temenoff JS. Interactions between mesenchymal stem cells, adipocytes, and osteoblasts in a 3D tri-culture model of hyperglycemic conditions in the bone marrow microenvironment. Integr Biol (Camb). 2014;6(3):324-337. doi:10.1039/c3ib40194d.
  12. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
  13. Rager TM, Olson JK, Zhou Y, Wang Y, Besner GE. Exosomes secreted from bone marrow-derived mesenchymal stem cells protect the intestines from experimental necrotizing enterocolitis. J Pediatr Surg. 2016;51(6):942-947. doi:10.1016/j.jpedsurg.2016.02.061.
  14. Tate-oliver K, Alexander RW. Density Platelet-Rich Plasma or Bone Marrow.
  15. Tang K, Yan J, Shen Y, et al. Tracing type 1 diabetic Tibet miniature pig ’ s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging. 2014;6:123-131. doi:10.1111/1753-0407.12084.
  16. Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Res. 2015;15(1):14-22. doi:10.1016/j.scr.2015.04.004.
  17. Rambaldi A, Capelli C, Domenghini M, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. 2007:785-791. doi:10.1038/sj.bmt.1705798.
  18. Mushtaq M, Williams AR, Suncion VY, et al. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy The TAC-HFT Randomized Trial. 2015;16960. doi:10.1001/jama.2013.282909.
  19. 2014 Autografting of bone marrow mesenchymal stem cells alleviates streptozotocin induced diabetes in miniature pigs.pdf.
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  21. Biology C, Cell R, Eye N, Institutes N, Infor- AS. Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms. 2017:1273-1285. doi:10.1002/sctm.12056.
  22. Jeong Y, Kyu H, Hwa H, Chan Y. Cellular Physiology and Biochemistr y Biochemistry Direct Comparison of Human Mesenchymal Stem Cells Derived from Adipose Tissues and Bone Marrow in Mediating Neovascularization in Response to Vascular Ischemia. Cell Physiol Biochem. 2007;20:867-876.
  23. Shutian S, Shaoping N, Xingxin W, et al. GW25-e3198 The combination of transforming growth factor β1 and 5-azacytidine improve the differentiation effects of rat Bone marrow mesenchymal stem cells into cardiomyocytes. J Am Coll Cardiol. 2014;64(16):C21. doi:10.1016/j.jacc.2014.06.105.
  24. Narita T, Suzuki K. Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. Heart Fail Rev. 2014:53-68. doi:10.1007/s10741-014-9435-x.
  25. Elman JS, Li M, Wang F, Gimble JM, Parekkadan B. A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation. J Inflamm (Lond). 2014;11:1. doi:10.1186/1476-9255-11-1.
  26. Dong X, Zhu F, Liu Q, et al. Transplanted bone marrow mesenchymal stem cells protects myocardium by regulating 14-3-3 protein in a rat model of diabetic cardiomyopathy. 2014;7(7):3714-3723.
  27. Huang L, Wu W, Luo F. Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes : A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. 2016:1-9. doi:10.2337/dc15-0171.
  28. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
  29. Leyh M, Seitz A, Dürselen L, et al. Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. 2014:1-18. doi:10.1186/s13075-014-0453-9.
  30. Surgery M, Stomatological S, Material CP, et al. T ISSUE -S PECIFIC S TEM C ELLS Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway : An Approach for Treating Bone Disease in Diabetes. 2015:240-252.
  31. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther. 2015;6(1):55. doi:10.1186/s13287-015-0066-5.
  32. Mead B, Logan A, Berry M, Leadbeater W, Scheven BA. Paracrine-Mediated Neuroprotection and Neuritogenesis of Axotomised Retinal Ganglion Cells by Human Dental Pulp Stem Cells: Comparison with Human Bone Marrow and Adipose-Derived Mesenchymal Stem Cells. PLoS One. 2014;9(10):e109305. doi:10.1371/journal.pone.0109305.
  33. Cao C, Zou J, Liu X, Shapiro A. Bone marrow mesenchymal stem cells slow intervertebral disc degeneration through the NF- k B pathway. Spine J. 2015;15(3):530-538. doi:10.1016/j.spinee.2014.11.021.
  34. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. ??? 2015. doi:10.1186/s13287-015-0066-5.
  35. Narita T, Suzuki K. Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. 2015:53-68. doi:10.1007/s10741-014-9435-x.
  36. Heldman AW, DiFede DL, Fishman JE, et al. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy. Jama. 2014;311(1):62. doi:10.1001/jama.2013.282909.
  37. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
  38. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-765. doi:10.1038/nm.2736.
  39. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
  40. Bian S, Zhang L, Duan L, et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl). 2014;92(4):387-397. doi:10.1007/s00109-013-1110-5.
  41. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296(6):H1888-H1897. doi:10.1152/ajpheart.00186.2009.
  42. Czubak PB, Bojarska-junak A, Tabarkiewicz J, Putowski LB. A Modified Method of Insulin Producing Cells ’ Generation from Bone Marrow-Derived Mesenchymal Stem Cells. 2014;2014:1-7. doi:10.1155/2014/628591.
  43. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
  44. am Esch JS, Knoefel WT, Klein M, et al. Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells. 2005;23(4):463-470. doi:10.1634/stemcells.2004-0283.
  45. Wang X, Nie S-P, Zhen L, et al. TCTAP A-156 Retrograde Coronary Vein Delivery of Basic Fibroblast Growth Enhances Bone Marrow Mesenchymal Stem Cells Engraftment for Myocardial Repair in a Canine Infarct Model. J Am Coll Cardiol. 2014;63(12):S44. doi:10.1016/j.jacc.2014.02.189.
  46. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
  47. Gabr MM, Zakaria MM, Refaie AF, et al. Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells : Evidence for Further Maturation In Vivo. 2015;2015.
  48. Pai M, Zacharoulis D, Milicevic MN, et al. Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis. Am J Gastroenterol. 2008;103(8):1952-1958. doi:10.1111/j.1572-0241.2008.01993.x.
  49. Kushida T, Iida H. Bone marrow cell transplantation efficiently repairs tendon and ligament injuries. Front Cell Dev Biol. 2014;2(July):1-4. doi:10.3389/fcell.2014.00027.
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  51. Scott M, Ph D, Marley SB, et al. Autologous Infusion of Expanded Mobilized Adult Bone Marrow-Derived CD34 + Cells Into Patients With Alcoholic Liver Cirrhosis. 2008:1952-1958. doi:10.1111/j.1572-0241.2008.01993.x.
  52. 2015 Murine Sca1+Lin− bone marrow contains an endodermal precursor population that differentiates into hepatocytes.pdf.
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  54. Naaldijk Y, Jäger C, Fabian C, et al. Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathol Appl Neurobiol. 2016:1-16. doi:10.1111/nan.12319.
  55. Nicola M Di, Carlo-stella C, Magni M, et al. induced by cellular or nonspecific mitogenic stimuli Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. 2013;99(10):3838-3843. doi:10.1182/blood.V99.10.3838.
  56. Tzameret A, Sher I, Belkin M, et al. Epiretinal transplantation of human bone marrow mesenchymal stem cells rescues retinal and vision function in a rat model of retinal degeneration. Stem Cell Res. 2015;15(2):387-394. doi:10.1016/j.scr.2015.08.007.
  57. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum. 2007;56(4):1175-1186. doi:10.1002/art.22511.
  58. Capelli C, Domenghini M, Borleri G, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40(8):785-791. doi:10.1038/sj.bmt.1705798.
  59. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
  60. Oe K, Kushida T, Okamoto N, et al. New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats. Stem Cells Dev. 2011;20(4):671-679. doi:10.1089/scd.2010.0182.
  61. Ahmed HH, Salem AM, Atta HM, et al. Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells. World J Stem Cells. 2016;8(3):106. doi:10.4252/wjsc.v8.i3.106.
  62. Cai J, Wu Z, Xu X, et al. Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. Diabetes Care. 2015:dc150171. doi:10.2337/dc15-0171.
  63. Abdel Aziz MT, Wassef MAA, Ahmed HH, et al. The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy. Diabetol Metab Syndr. 2014;6(1):34. doi:10.1186/1758-5996-6-34.
  64. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
  65. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296(6):H1888-H1897. doi:10.1152/ajpheart.00186.2009.
  66. Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5(7). doi:10.1371/journal.pone.0011803.
  67. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
  68. Fekete N, Rojewski MT, Fürst D, et al. GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PLoS One. 2012;7(8). doi:10.1371/journal.pone.0043255.
  69. C. L, S.A. M, M. A, S.H. V, A. F-G. Exosomes mediate the cytoprotective effects of bone Marrow-Derived Stromal Cells (MSCS) on the hypoxic lung. Am J Respir Crit Care Med. 2011;183(1 MeetingAbstracts):no pagination. http://ajrccm.atsjournals.org/cgi/reprint/183/1_MeetingAbstracts/A3764?sid=f0b58cd0-9f08-401b-bb88-e9a3268d044f%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=70848115.
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  71. Yoon SH, Shim YS, Park YH, et al. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells. 2007;25(8):2066-2073. doi:10.1634/stemcells.2006-0807.
  72. Hernigou P, Guissou I, Homma Y, et al. Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes. Int Orthop. 2015. doi:10.1007/s00264-015-2738-2.
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  75. Tang KX, Shen YF, Li BY, et al. Tracing type 1 diabetic Tibet miniature pig’s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging. J Diabetes. 2013;6:123-131. doi:10.1111/1753-0407.12084.
  76. Associates RM, Biosciences C. T RANSLATIONAL AND C LINICAL Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months. 2015:146-156.
  77. Kasahara Y, Matsuyama T, Taguchi A. Treatment of Autologous Bone Marrow Mononuclear Cells for Acute and Subacute Stroke Cell Therapy for Acute / Subacute Stroke. 2015:37-46. doi:10.1007/978.
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Patient Services at ANOVA Institute for Regenerative Medicine

  • Located in the center of Germany, quick access by car or train from anywhere in Europe
  • Simple access worldwide, less than 20 minutes from Frankfurt Airport
  • Individualized therapy with state-of-the-art stem cell products
  • Individually planned diagnostic work-up which include world-class MRI and CT scans
  • German high quality standard on safety and quality assurance
  • Personal service with friendly, dedicated Patient Care Managers
  • Scientific collaborations with academic institutions to assure you the latest regenerative medical programs