Why We Age
Aging is a complex biological process in which cells become progressively damaged over time and eventually die. As we age, fewer and fewer cells are replaced, slowly wearing out our bodies. This means that over time the damage accumulated in our bodies will become so immense, that at one point the body will not be able to cope with it - ultimately leading to our death.
Environmental factors such as: exposure to sun - "solar radiation", injuries, smoking, air and water pollution, etc., and genetics contribute to speeding up the process of aging as well.
Aging affects our skin negatively by disturbing the normal function of skin cells. A majority of diseases are a result of aging. Our skin cells experience enormous amount of damage on a daily basis. They are exposed to constant bombardment of tens of thousands harmful elements each day, causing irregular pigmentation (skin discoloration or hyperpigmentation) and loss of elasticity in skin.
Aging is involved in many other processes, such as accumulation of senescent cells, oxidative stress, immune and hormonal system changes. All of these factors contribute to increasing the risk of cancerous diseases.
Effects of ANOVA's reYOUvenation on Anti-Aging
Stem cells are the solution of the future, because they tackle the problem on a cellular level. Expensive beauty creams and cosmetics promise only temporary or superficial solutions to your aging problems. Most of them function by masking the processes of aging on the surface level, but never offer solid solutions to where aging really happens.
Latest research in regenerative science provides concrete evidence that aging actually takes place at the cellular level. This is where aging needs to be stopped!
Would you like to learn more about Stem Cell Treatment for Anti-Aging?
Then give us a call!
ANOVA offers advanced and novel stem cell-based therapies for Anti-Aging and regeneration. Our treatments are potentially capable of repairing the effects of aging - effectively extending your life. They act on the cellular level, by optimizing and revitalizing the functions of your whole body, not just the surface. Our medical specialists make use of your own stem cells to rejuvenate you and make you feel young and powerful again!
We are the Science of a Younger You!
All stem cell-based procedures at ANOVA are personalized and in full accordance with the strict quality standards of Germany and the respective healthcare regulations.
The medical diagnostics team at ANOVA will help you obtain a general idea of your body’s current health status by performing:
* In-depth medical history
* General physical exam
* Personalized clinical chemistry
(blood and urine)
* Cardio-vascular evaluation including
(EKG, Echocardiography, Cardio-CT, MRI, etc.)
* Cancer check with tumor markers
* Whole-body MRI
* Virtual colonoscopy
* Low-dose CT of the lungs (smoker)
* MR-mammography, etc.
Additional anti-aging treatments may include:
* Metabolic and body composition optimization
* Hormone optimization
* Antioxidation treatment
* Dietary optimization
* Personalized exercise program
Relevant Information on Stem Cell-based Therapies in Real Life
Repair of injured spinal cord using biomaterial scaffolds and stem cells
Paralyzed man walks again after cell transplant
Christopher and Dana Reeve Foundation
Stem cell clinical trial aims to combat nerve damage in human tissue
Park, Byung-Soon, and Won-Serk Kim. "Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss." Textbook of Aging Skin (2017): 205-224.
Xu, Dan, and Hidetoshi Tahara. "The role of exosomes and microRNAs in senescence and aging." Advanced drug delivery reviews 65.3 (2013): 368-375.
Prattichizzo, Francesco, et al. "Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging." Mechanisms of Ageing and Development (2017).
Basu, Joydeep, and John W. Ludlow. "Exosomes for repair, regeneration and rejuvenation." Expert opinion on biological therapy 16.4 (2016): 489-506.
Park, Byung-Soon, and Won-Serk Kim. "Adipose-derived stem cells and their secretory factors for skin aging." Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. 201-212.
Soto-Gamez, A., & Demaria, M. (2017). Therapeutic interventions for aging: the case of cellular senescence. Drug Discovery Today.
Moiseeva, O. et al. (2013) Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kB activation. Aging Cell 12, 489–498.
Martin-Montalvo, A. et al. (2013) Metformin improves healthspan and lifespan in mice. Nat. Commun. 4, 2192.
Pitozzi, V. et al. (2013) Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts. J. Gerontol. A Biol. Sci. Med. Sci. 68, 371–381.
Lim, H. et al. (2015) Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts. Biochem. Pharmacol. 96, 337–348.
Toso, A. et al. (2015) Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors: a way to reactivate the antitumor immunity. Oncoimmunology 4, e994380.
Xu, M. et al. (2015) Targeting senescent cells enhances adipogenesis and metabolic function in old age. eLife 4, e12997.
Liou, C.J. et al. (2014) Oral lovastatin attenuates airway inflammation and mucus secretion in ovalbumin-induced murine model of asthma. Allergy Asthma Immunol. Res. 6, 548–557.
Mian, B.M. et al. (2003) Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB. Clin. Cancer Res. 9, 3167–3175.
Karkera, J. et al. (2011) The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a Phase I study. Prostate 71, 1455–1465.
Pellegrini, G. et al. (2004) Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes. Eur. J. Cell Biol. 83, 691–700.
Abad, M. et al. (2013) Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340–345.
Sagiv, A. et al. (2013) Granule exocytosis mediates immune surveillance of senescent cells. Oncogene 32, 1971–1977.
Demaria, M. et al. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 31, 722–733.
Pei, Ming. "Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential." Biomaterials (2016).
Vañó-Galván, S., and F. Camacho. "New Treatments for Hair Loss." Actas Dermo-Sifiliográficas (English Edition) (2017).
Anitua, Eduardo, Ander Pino, and Gorka Orive. "Opening new horizons in regenerative dermatology using platelet‐based autologous therapies." International journal of dermatology 56.3 (2017): 247-251.
Located in the center of Germany, less than 20 minutes from Frankfurt Airport
