The ANOVA Infusion Plans Germany

Every infusion plan is composed individually by your physician, after a review of your medical history, your current medication and recent blood tests. If you already know what you would like, you can request further information directly. The infusions can be given during a stay for senescent cell removal, at an MSC secretome (MSEC) application visit, or at a separate appointment as a day patient. Infusion therapy does not replace a balanced diet, medical treatment of a diagnosed deficiency or your regular care.

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In infusion therapy, a solution of nutrients is given directly into a vein, so it does not depend on absorption in the gut. Our infusion plans can combine vitamins, amino acids, trace elements, antioxidants and NAD+, a coenzyme needed for cellular energy metabolism. They complement the two treatments of our anti-ageing programme, senescent cell removal and mesenchymal stem cell secretome therapy, and can also be booked on their own.

More details are in our scientific section.

• Focus: healthy ageing
• Focus: immune system
• Focus: nervous system
• Focus: athletes
• Focus: cellular energy

How the infusion plans can be combined with senescent cell removal and MSEC is shown in the example programmes on our anti-ageing page.

Depending on your focus, different infusions may be suitable. Your physician composes them individually from the following groups of substances:

• Vitamins
• Amino acids
• Trace elements and minerals
• Antioxidants
• Polyamines
• Coenzymes, including NAD+
• Basic infusion solutions

Infusion therapy should be seen as a complement to conventional treatment. It is not a disease treatment in its own right, and in serious illness it does not replace disease-specific medication. For athletes subject to doping controls, it must be checked before treatment whether the individual infusion is permitted under the WADA anti-doping rules.

What research knows about the individual components, including the studies, is described in the clinical and scientific section below.

Talk to us about which infusion plan suits you and how it can be combined with our other treatments, or request further information.

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Both institutions are located in the same building in Offenbach and are owned by Dr. Stehling.

• Vitus Privatklinik: a licensed private clinic; its physicians decide on and give the infusions, as a day patient or during an inpatient stay, and carry out the related blood tests.
• ANOVA IRM: your contact for questions and appointments; it produces and applies MSEC, which can be combined with the infusions.
• The infusion solutions are prepared individually for you by a specialised pharmacy under sterile conditions, as pharmacy-compounded preparations (Rezepturarzneimittel).

Your wishes and medical history are first reviewed remotely, by phone or video. The infusions take place in person in Offenbach am Main, less than 20 minutes from Frankfurt Airport. You receive an individual written cost estimate before any treatment decision.

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The price of an infusion plan ranges from €403.41 to €1,285.20, including 19% VAT, and depends on the individual plan:

• Focus: healthy ageing
• Focus: immune system
• Focus: nervous system
• Focus: athletes
• Focus: cellular energy

The costs consist of two parts:

• Day-patient or inpatient admission to the clinic: a day-patient stay costs approximately €238 to €476, depending on its length, and an overnight stay approximately €595, each including 19% VAT. During a stay for senescent cell removal, the stay is already covered by its flat rate.
• The individual infusions: from €403.41 to €1,285.20 per infusion plan, including 19% VAT.

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• Initial consultation: remote, by phone or video, before you travel; recent blood tests and your medication list are reviewed.
• Infusion series: given on one or several days, as a day patient or during a stay for senescent cell removal or an MSEC visit.
• Review: your physician reviews tolerability and, where relevant, blood test results before any further series.
• Further series: if you wish, repeated at intervals that your physician plans with you; there is no fixed maintenance schedule.

Infusion therapy is intended for adults who want medically supervised infusions as part of an individual approach to healthy ageing and longevity. A consultation and recent blood tests are required beforehand. Every treatment recommendation follows a medical assessment, and a request for a consultation does not mean that treatment will be offered.

What are the contraindications for infusion therapy?

Our treatments are experimental. We treat only people for whom, after medical assessment, we consider the benefit-risk balance to support treatment.

Applies to all ANOVA treatments:

• Active cancer within the last two years
• Under the age of legal majority
• Pregnancy or breastfeeding
• Active infectious disease (hepatitis A, B, C, HIV, syphilis or other)

Specific to infusion therapy:

• Known allergy to a component of the infusion
• Severe kidney disease or a history of kidney stones, for infusions with high-dose vitamin C
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency, for infusions with high-dose vitamin C
• Severe heart failure, because of the fluid volume of the infusion
• Blood test results that speak against treatment

• Consultation: we review your medical history, current medication and recent blood tests remotely; your physician recommends an infusion plan.
• Blood tests before the first infusion: blood count, kidney and liver function and electrolytes; before infusions with high-dose vitamin C also the G6PD activity.
• Infusion: a physician of the Vitus Privatklinik places a small cannula in a vein; blood pressure, pulse and oxygen saturation are checked before, during and after the infusion.
• Rate and observation: the infusion rate is adjusted if you notice flushing, chest tightness or nausea, and you are observed for a short time afterwards.
• Follow-up: with longer or repeated series, kidney and liver values are checked again.

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Several processes linked to ageing, among them mitochondrial dysfunction and chronic inflammation, depend on a sufficient supply of nutrients and coenzymes.^[1] When vitamins are taken by mouth, absorption in the gut limits how high their blood levels can rise. Given into a vein, vitamin C, for example, reaches blood levels many times higher than with the largest tolerated oral doses.^[2] The idea of infusion therapy is to use this route to supply nutrients quickly and reliably. Other processes linked to ageing, such as the accumulation of senescent cells, are addressed by the further treatments of our anti-ageing programme.

In conventional medicine, a deficiency is diagnosed with blood tests and usually treated with tablets or a change of diet. Infusions are used where tablets are not enough or cannot be absorbed, for example in severe iron or vitamin B12 deficiency. Infusion plans for healthy people go beyond this established use.

What does infusion therapy not replace?

It does not replace the diagnosis and treatment of a deficiency or disease by your own doctors. Blood test results that need further investigation are passed on to you and, with your consent, to your treating doctors.

What are vitamins, and what does the body need them for?

Vitamins are organic nutrients that the body cannot produce, or cannot produce in sufficient amounts; it needs them for energy metabolism, immune defence and the renewal of cells and tissue. In an external randomised placebo-controlled study in 141 healthy office workers, a single high-dose vitamin C infusion reduced fatigue for up to one day.^[3] In a randomised placebo-controlled study in healthy people aged 65 and over, vitamin E taken by mouth for eight months improved several measures of the immune response.^[5] A small pilot study of a common vitamin and mineral infusion found improvements in both groups, but no clear difference from placebo.^[4]

Infusions can be combined with MSEC, an autologous MSC secretome (see process, eligibility and cost). The mesenchymal stem cell secretome, or MSC secretome, is also called the mesenchymal stromal cell secretome. Mesenchymal stem cells and mesenchymal stromal cells are two names for the same cells (MSC); the International Society for Cell & Gene Therapy recommends “stromal” for cells grown in the laboratory. MSEC is therefore a mesenchymal stromal cell secretome made from your own cells.

What are trace elements and minerals, and what does the body need them for?

Trace elements and minerals are inorganic nutrients that the body needs in small amounts, for example for enzymes, for nerve and muscle function and for its own antioxidant defence. In a meta-analysis of eleven randomised controlled studies, magnesium supplements lowered the inflammation marker C-reactive protein in people with raised levels.^[6] In an external randomised placebo-controlled study in 443 older adults, selenium combined with a coenzyme, taken by mouth for four years, was followed by fewer cardiovascular deaths than placebo.^[7]

What are amino acids, and what does the body need them for?

Amino acids are the building blocks of proteins; the body needs them for muscles, enzymes and messenger substances, and some of them are precursors of its own antioxidants. In a small external randomised placebo-controlled study in 24 older adults, a combination of two amino acids taken by mouth for 16 weeks raised the level of the body’s own antioxidants. Markers of oxidative stress and inflammation fell, and physical performance improved.^[8]

What are antioxidants, and what does the body need them for?

Antioxidants protect cells from damage by reactive oxygen compounds, which arise in normal metabolism and increase with inflammation and age. In an external randomised placebo-controlled study over six months, an antioxidant that the body also produces itself, taken by mouth, increased its stores in the blood and in other cells.^[9]

What are polyamines, and what does the body need them for?

Polyamines are produced by the body and support autophagy, the recycling system of the cell, which becomes less effective with age.^[1] In a small external randomised pilot study in older adults with subjective memory complaints, a polyamine-rich plant extract taken by mouth for three months improved memory performance compared with placebo.^[10] A larger external randomised study over twelve months did not confirm this effect.^[11]

What is NAD+, and what does the body need it for?

NAD+ is needed for cellular energy metabolism and DNA repair, and raising its declining levels is one of the central ideas of current ageing research.^[12] In laboratory and animal studies, higher NAD+ levels improved mitochondrial function and several signs of ageing.^[12] In a small external pilot study, an NAD+ infusion raised NAD+ levels in the blood of healthy men and was well tolerated.^[13] In an external randomised study in 30 healthy adults aged 55 to 79, an oral NAD+ precursor taken for six weeks raised NAD+ levels and was well tolerated; exploratory analyses suggested lower blood pressure.^[14] Clinical studies have not yet been able to confirm an effect on ageing.^[15]

What is known about side effects of high-dose vitamin C infusions?

In a large external survey of practitioners, side effects of intravenous vitamin C were reported mostly as minor, such as tiredness and irritation of the vein.^[16] Serious complications occurred in people with G6PD deficiency or pre-existing kidney disease. For this reason, these conditions are checked before such infusions.^[16]

The infusion plans are adapted as research develops. Talk to us about current changes or additions.

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We have no evaluated dataset of our own for infusion therapy. What we can say rests on the published literature and on the rationale described above; individual results vary.

What is the realistic goal of infusion therapy?

The goal is a medically supervised supply of nutrients and NAD+ as part of an individual approach to healthy ageing, with the dose and composition checked by a physician. A longer life, better performance or the prevention of any disease cannot be promised.

The infusions are given by physicians of the Vitus Privatklinik, a private clinic licensed under Section 30 of the German Trade Regulation Act (Gewerbeordnung). The infusion solutions are prepared individually for each patient by a specialised pharmacy as pharmacy-compounded preparations (Rezepturarzneimittel), which do not require a marketing authorisation. Your physician explains the composition, the evidence and the risks before treatment.

Questions people usually ask next. Each is answered in full on its own page.

• Who are we?
• Is ANOVA legal?
• Is stem cell therapy safe?
• What is MSC secretome (MSEC)?
• What is BMC (Bone Marrow Concentrate)?
• What are stem cells?
• What should I ask when looking for a stem cell treatment?
• Which conditions do we treat?
• The ANOVA Anti-Ageing Programme

Request a Consultation → Request Further Information →

ANOVA IRM shares its premises in Offenbach with two further institutions owned by Dr. Stehling: the Institut für Bildgebende Diagnostik (IBDO), providing MRI and CT imaging, and the VITUS PRIVATKLINIK Prof. Dr. Stehling GmbH, where the infusion therapies take place. Because imaging is carried out in the same building, examinations can be performed in-house. See diagnostics at ANOVA IRM.

Ageing, vitamins, trace elements, amino acids and antioxidants

• [1] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243–278. doi:10.1016/j.cell.2022.11.001. PMID: 36599349.
• [2] Padayatty SJ, Sun H, Wang Y, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004;140(7):533–537. doi:10.7326/0003-4819-140-7-200404060-00010. PMID: 15068981.
• [3] Suh SY, Bae WK, Ahn HY, et al. Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial. Nutr J. 2012;11:7. doi:10.1186/1475-2891-11-7. PMID: 22264303.
• [4] Ali A, Njike VY, Northrup V, et al. Intravenous micronutrient therapy (Myers’ Cocktail) for fibromyalgia: a placebo-controlled pilot study. J Altern Complement Med. 2009;15(3):247–257. doi:10.1089/acm.2008.0410. PMID: 19250003.
• [5] Meydani SN, Meydani M, Blumberg JB, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial. JAMA. 1997;277(17):1380–1386. doi:10.1001/jama.1997.03540410058031. PMID: 9134944.
• [6] Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, et al. Effect of magnesium supplementation on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Curr Pharm Des. 2017;23(31):4678–4686. doi:10.2174/1381612823666170525153605. PMID: 28545353.
• [7] Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013;167(5):1860–1866. doi:10.1016/j.ijcard.2012.04.156. PMID: 22626835.
• [8] Kumar P, Liu C, Suliburk J, et al. Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2023;78(1):75–89. doi:10.1093/gerona/glac135. PMID: 35975308.
• [9] Richie JP Jr, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015;54(2):251–263. doi:10.1007/s00394-014-0706-z. PMID: 24791752.

Polyamines

• [10] Wirth M, Benson G, Schwarz C, et al. The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial. Cortex. 2018;109:181–188. doi:10.1016/j.cortex.2018.09.014. PMID: 30388439.
• [11] Schwarz C, Benson GS, Horn N, et al. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial. JAMA Netw Open. 2022;5(5):e2213875. doi:10.1001/jamanetworkopen.2022.13875. PMID: 35616942.

NAD+

• [12] Covarrubias AJ, Perrone R, Grozio A, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119–141. doi:10.1038/s41580-020-00313-x. PMID: 33353981.
• [13] Grant R, Berg J, Mestayer R, et al. A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6 hour intravenous infusion of NAD+. Front Aging Neurosci. 2019;11:257. doi:10.3389/fnagi.2019.00257. PMID: 31572171.
• [14] Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9:1286. doi:10.1038/s41467-018-03421-7. PMID: 29599478.
• [15] Vinten KT, Trętowicz MM, Coskun E, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nat Metab. 2025;7(10):1974–1990. doi:10.1038/s42255-025-01387-7. PMID: 41083806.

Safety of intravenous micronutrients

• [16] Padayatty SJ, Sun AY, Chen Q, et al. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010;5(7):e11414. doi:10.1371/journal.pone.0011414. PMID: 20628650.

General MSC, extracellular vesicle and secretome literature is maintained on the MSC secretome page.