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Unterschiedliche Krankheiten mit verschiedenen Ursachen erfordern unterschiedliche Therapien.
Daher verwendet die ANOVA verschiedene Arten von Stammzellen aus unterschiedlichen Geweben. Lesen Sie hier mehr über die verschiedenen Typen von Stammzellen und Ihre Verwendungsmöglichkeiten.
Knochenmarkkonzentrat (Bone Marrow Concentrate, BMC) ist eine der am häufigsten verwendeten Stammzellquellen, die früher von vielen Orthopäden eingesetzt wurde. Eine schnelle, minimalinvasive Methode um eine begrenzte Anzahl an Stammzellen für die meist lokale Therapie im Gelenk bei Arthrose oder Verletzungen zu gewinnen. Externe internationale Studienergebnisse konnten zeigen, dass der Cocktail aus (regenerativen) Faktoren in BMC vielversprechende Ergebnisse bei der Behandlung zahlreicher Krankheiten liefern.
Die ANOVA Stammzell-Sekretom-Therapie ist die
zweite Generation stammzellbasierter Therapien. Sie wurde entwickelt, um für die Behandlung chronischer Erkrankungen die aktiven Substanzen einer großen Menge von Stammzellen (patientenindividuelle Mischung aus z.B. entzündungshemmenden, immunmodulierenden Stoffen, Vesikeln, Exosomen) als sogenanntes Sekretom in einem sicheren Laborprozess zu gewinnen und lagern zu können.
Dies ermöglicht eine mehrfache Anwendung über Monate.
Thrombozytenreiches Plasma (englisch: Platelet-Rich-Plasma, PRP) ist ein aus Blut gewonnenes zelluläres Produkt welches einen hohen natürlichen Anteil an regenerativen Wachstumsfaktoren und Zytokinen aufweist. Die Wirksamkeit wurde für bestimmte orthopädische Anwendungsgebiete in externen Studien nachgewiesen. Wir empfehlen PRP in Kombination mit Stammzelltherapien für die langfristige Therapie oder als einfache Alternative.
Was sind Stammzellen? Woher kommen sie? Wie wirken Sie? Und wie können sie verwendet werden? Diese und mehr Fragen adressieren wir auf unserer „Über Stammzellen“ Seite
Numerous types of stem cell therapies are available at ANOVA. Stem cell research brought insights that allowed for technological advancements in therapies and expanding the knowledge of the underlying mechanisms of stem cells. This has allowed for more effective therapies to be developed.
Bone Marrow Concentrate (BMC) is one of the most commonly applied source of stem cells. Despite the fact that the actual number of stem cells in BMC is biologically limited, several other (regenerative) factors in BMC have been shown to deliver promising results in the treatment of numerous diseases.
Stem Cell Therapies 2.0: The ANOVA Stem Cell Secretome Therapy is the next generation of stem cell-based therapies. It was designed to harness and mass produce the healing essences of stem cells (paracrine and regenerative factors, extracellular vesicles, exosomes) in a uniquely designed laboratory process.
Fat (adipose) derived Mesenchymal Stem Cells (MSC | adMSCs) are a commonly used source of stem cells, because of their availability and robustness. They communicate to other cells with a broad spectrum of secreted paracrine and regenerative factors. They are our favorite source of stem cells for the production of the secretome.
Platelet Rich Plasma (PRP) is a blood-derived, cellular product with concentrated supply of regenerative growth factors and cytokines. Its efficacy has been proven in some orthopedic conditions. When used in combination with our stem cell therapies, its efficacy is synergistically enhanced.
Loud crunching when climbing stairs, chronic pain and constant swelling: osteoarthritis in the knee is a very uncomfortable type of pain. If you suffer from knee problems like the ones described, knee surgery is one option. But is that really always necessary? What therapeutic alternatives are there? In this post, we'll give you a few options that might help with your knee pain.
How well does stem cell therapy for erectile dysfunction work? Are clinical results available, and if so, what do they show? In this article, we share some research insights on stem cell therapy for the treatment of erectile dysfunction, and talk about a success story of one of our patients who was treated for ED at ANOVA Institute for Regenerative Medicine.
Erectile dysfunction (ED), also known as impotence, affects nearly half of all men between the ages of 40 and 70 in one way or another. ED is defined as a disease which makes it impossible for a man to have a sufficient erection for sexual intercourse. Naturally, sexual dysfunctions are accompanied with a lot of stress for patients and their partners. In this article, we summarize the causes of ED, common treatments, and how stem cells can help treat the disease in a promising way.
Rejuvenation therapy is a form of medical treatment with the focus to halt, alter and even reverse the aging process. While there is currently no scientifically proven way to delay our internal aging processes themselves, there are ways to alter or delay some of the effects we experience as we age. Stem cell therapy is on the rise as a rejuvenation treatment. In this article, we discuss the differences between the various stem cell therapies for anti-aging.
Parkinson's Disease (PD) is one of the most common diseases of the nervous system. There is currently no cure for the disease. Common treatments aim at easing symptoms and reducing side effects as much as possible. A big part of the therapy usually includes medication. But are there other options? Can alternative treatments enhance the effect of typical PD therapies, or even stop the progression of the disease? Here we provide an overview of treatment options for PD.
Amyotrophic lateral sclerosis (ALS) is a very serious disease of the central and peripheral nervous system. With the exception of the rare hereditary forms, its cause is still unknown. Even though they are often compared, ALS has nothing to do with MS (Multiple Sclerosis) - they are two completely different diseases.
The term “exosomes” has frequently been in the news in recent years. They have been known to biologists since their discovery in the 1980s, but they remain something unknown to most other people. As their relevance in the pharmaceutical and medical field increases, we want to explain in simple ways what exosomes are, and why they are disrupting science.
Degenerative disc disease (DDD) is one of the most common sources of back pain and affects approximately 30 million people every year. It can lead to a chronic debilitating condition and can have a serious negative impact on a person's quality of life.
As kids, nasty grazes aside, we may not have thought a lot about our knees. As adults, our situation is a little different. We may feel our joints hurt a little more often. However, it’s not only those entering their twilight years who are susceptible to knee pain and degeneration. Anyone trying to maintain an active lifestyle or doing regular physical exercise will be no stranger to knee injuries.
All around the world, patients with various diseases are turning to stem cell-based treatments to improve their conditions. People with orthopedic issues are no exception.
In this article, we’ll discuss the different orthopedic conditions and how stem cell therapy can help alleviate their symptoms and tackle their root cause.
If you, or perhaps someone close to you, suffers with a challenging illness, you may be exploring viable alternative treatments. You may even have come across stem cell therapy as an avenue to explore. But where do you start? And could you even afford it?
There are 2.3 million people around the world who are suffering from Multiple Sclerosis, according to the National Multiple Sclerosis Society. In the US alone, over a million people over the age of 18 are afflicted with this disease.
Knee injuries aren’t uncommon for athletes and runners. While getting injured is all part of the game, your journey to recovery shouldn’t be a difficult one.
Osteoarthritis (OA) affects millions worldwide and while it is common among the elderly, people below 60 years can also be affected by the illness.
Traumatic Spinal Cord Injury is a prevalent problem that affects millions of people world-wide. Current treatment options do not provide help for the regeneration of the spinal cord. The combination of Stem Cell Therapy with neuromuscular feedback training with HAL may advance success rates in patients with Spinal Cord Injury
ANOVA Institute for Regenerative Medicine is partnering with experts at Copenhagen Stem to help patients with Dry Mouth Syndrome to regenerate their salivary gland function with Stem Cell Therapy.
Infusion Therapy is a way to administer medication, vitamins, nutrients and other molecules into the body, by using a sterile catheter that is inserted into a vein. It is an alternative to oral treatment, and can be the fastest way to deliver these vital compounds into your body.
The human body consists of several complex functional systems encompassing the brain, spinal cord, peripheral nerves and bones and muscles, among others. The damage of one of these units can cause the whole system to fail.
Parkinson's Disease (PD) is a chronic nervous system disorder that affects the patient’s movement. Symptoms will usually start gradually, with tremors being the most common symptom, but the disorder can also cause stiffness or slowed down movement.
ANOVA Institute for Regenerative Medicine is now offering Platelet-Rich Plasma (PRP) on its own or in combination with other therapies such as Bone Marrow Concentrate (BMC) or hyaluronic acid for the effective treatment of different orthopedic problems.
A New Generation of Stem Cell Therapy Launches To The Public The ANOVA Institute for Regenerative Medicine in Frankfurt / Germany has become the first clinic to introduce Stem Cell Secretome therapy – the very latest Stem Cell therapy derived from decades of research into the stem cell techniques used for regeneration in the body.
Being one of a kind clinic with dedication to translational medicine and stem cell based therapies at the highest standard in the center of Europe, we want to message our services and products as efficiently as possible to all patients interested in the latest regenerative approaches.
Cellular Senescence is a state of cells where cells stop taking an active dividing role in the tissue, but at the same time refuse to react to the natural signals to apoptosis (“cellular suicide”). This state does not only leave them as useless and inactive cells, but they also secrete substances (cytokines and extracellular vesicles)...
Step 1 - Harvesting Mesenchymal Stem Cells (MSCs) from subcutaneous adipose tissue.
At Anova IRM, we use the most advanced harvesting technique to date, the so-called "nutational infrasonic liposuction", employing the Euromi Lipomatic® system. This procedure provides 10 to 100 times more viable MSCs obtained from the harvested adipose tissue than any other technique.
In a point-of-care setting, like at Anova, the adipose tissue is immediately processed according to current highest standards, guaranteeing the highest quality of the end product.
Step 2 - Processing the Stem Cells and designing the Stem Cell Secretome (SCS)
In our specialized laboratories, the “stromal vascular fraction” (SVF) is isolated from adipose tissue after enzymatic digestion. The SVF is a mixture of different types of cells. It contains a high percentage of MSCs (equivalent of up to 500.000 cells per gram), and is one of the highest amounts of MSCs to be found in the human body.
By subjecting the cells to external stimuli, they can be stimulated to secrete a high concentration of cytokines, micro-RNAs and growth factors (that retain regenerative abilities) that are packed in extracellular vesicles (microvesicles and exosomes). Together, these factors make up the secretome.
In the next step the cells are laboratory grown and expanded, where the MSCs are obtained by special technique. These MSCs can now be used for the mass production of the Mesenchymal Stem Cell Secretome (MSEC). MSEC consists of a high concentration of the extremely effective healing substances that are secreted by the MSCs.
The stem cell secretome is ready for use, and can be stored for several months at minus 80°C. This makes it possible to design a therapy plan that allows for several infusions (over several years) and favors optimal treatment outcomes possible.
Step 3 - Application and treatment with Anova’s Stem Cell Secretome therapy
From a single isolation of stem cells, from the liposuction of the adipose tissue, up to 10 therapeutic doses can be obtained that are to be administered systemically via an infusion. The first application of SSEC is possible 3 days after liposuction, while the earliest application of MSEC is possible 21 days after liposuction. During that time, our specialists in the laboratory prepare and concentrate the product. In parallel, several pharmaceutical level quality tests are conducted to verify that the product is safe and of the highest quality standards, that we are aiming for.
Osteoarthritis (OA) affects millions worldwide and while it is common among the elderly, people below 60 years can also be affected by the illness.
Loud crunching when climbing stairs, chronic pain and constant swelling: osteoarthritis in the knee is a very uncomfortable type of pain. If you suffer from knee problems like the ones described, knee surgery is one option. But is that really always necessary? What therapeutic alternatives are there? In this post, we'll give you a few options that might help with your knee pain.
How well does stem cell therapy for erectile dysfunction work? Are clinical results available, and if so, what do they show? In this article, we share some research insights on stem cell therapy for the treatment of erectile dysfunction, and talk about a success story of one of our patients who was treated for ED at ANOVA Institute for Regenerative Medicine.
Erectile dysfunction (ED), also known as impotence, affects nearly half of all men between the ages of 40 and 70 in one way or another. ED is defined as a disease which makes it impossible for a man to have a sufficient erection for sexual intercourse. Naturally, sexual dysfunctions are accompanied with a lot of stress for patients and their partners. In this article, we summarize the causes of ED, common treatments, and how stem cells can help treat the disease in a promising way.
Rejuvenation therapy is a form of medical treatment with the focus to halt, alter and even reverse the aging process. While there is currently no scientifically proven way to delay our internal aging processes themselves, there are ways to alter or delay some of the effects we experience as we age. Stem cell therapy is on the rise as a rejuvenation treatment. In this article, we discuss the differences between the various stem cell therapies for anti-aging.